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Alphamab Oncology will Present Phase I Clinical Data of KN046 and KN026 at the 2020 ASCO Annual Meeting

May 14, 2020 12:55 Eastern Daylight Time

Suzhou, May 14, 2020 - Alphamab Oncology (stock code: 9966 HK) announced today that Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (“Jiangsu Alphamab”), a wholly-owned subsidiary of the Company, has achieved promising results for the Phase I clinical trials of KN046 (PD-L1/CTLA4 bispecific antibody) and KN026 (HER2 bispecific), these clinical data will be presented at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting.


ASCO is the world’s largest and unarguably the most influential oncology organization. The ASCO Annual Meeting brings together tens of thousands of oncology professionals from around the world each year and is widely recognized as one of the world's most important oncology conferences. Due to the outbreak of COVID-19, 2020 ASCO annual meeting will take place online. Jiangsu Alphamab will present:


Title: The preliminary efficacy and safety data of KN046 (bispecific anti-PD-L1/CTLA4) in patients failed on prior immune checkpoint inhibitors therapy

Abstract No.:#3020

Time: May 29, 2020, 8:00 AM – 11:00 AM, EDT


Title: Preliminary Safety, Efficacy and Pharmacokinetics Results of KN026, a HER2-targeted Bispecific Antibody in Patients with HER2-positive Metastatic Breast Cancer

Abstract No.:#1041

Time: May 29, 2020, 8:00 AM – 11:00 AM, EDT


Dr. Ting Xu, Founder, Chairman and CEO of Alphamab Oncology, said: "KN046 and KN026 are innovative biological drug candidates developed using our two bispecifics platforms. We are pleased to see that the latest clinical data further validate the safety and efficacy of KN046 and KN026, and that will continue to support the development of subsequent clinical trials. Currently, PD-1 is only effective in less than 30% solid cancer patients. Patients who fail to respond to PD-1 only have very limited options. We will further validate the efficacy of K046 as monotherapy and combos with other drugs in late stage cancer patients who have failed PD-1 treatments. For KN026, based on the favorable efficacy, we will conduct clinical trials as first line therapy in HER2-positive solid tumors as soon as possible. We look forward to bringing these two promising innovative oncology drugs to market soon, and making these new treatment options available to patients globally.”


KN046 is the world's first recombinant humanized PD-L1/CTLA-4 bispecific antibody independently developed by Jiangsu Alphamab. It is currently in Phase II clinical trials in China and the United States, with results showed that KN046 is in line with the safety data of other single-target immuno-checkpoint inhibitors previously reported. KN046 also has shown exciting preliminary clinical results in patients with advanced solid tumors who previously failed immuno-checkpoint inhibitor treatment.


KN026 is an anti-HER2 bispecific antibody developed by Jiangsu Alphamab using the proprietary Fc-based heterodimer bispecific platform technology called CRIB. Currently, KN026’s Phase I dose expansion clinical research has been carried out in China and the United States, with several Phase II clinical trials are ongoing in China, including combo with chemotherapy as HER2-positive metastatic breast cancer first-line treatment, monotherapy for metastatic breast cancer with HER2 low and medium expression which have failed standard treatment, monotherapy as the second-line therapy for late stage gastric cancer with HER2 overexpression or medium-to-low HER2 expression, to further explore the efficacy and safety of KN026 in different patients with advanced solid tumors. The results of Phase I clinical trials show KN026 has encouraging anti-tumor activity in HER2-positive breast cancer patients who progressed after multiple lines of anti-HER2 treatment.


We will release posters simultaneously on our website on May 29, 8:00 AM – 11:00 AM, EDT. Click here (www.alphamabonc.com/en/technology/publications)to find out the latest clinical data of KN046 and KN026 published on ASCO.


About Alphamab Oncology

Alphamab Oncology is a biopharmaceutical company focusing on innovative biologics medicine for oncology. On December 12, 2019, the Company was listed in the mainboard of Hong Kong Stock Exchange with stock code 9966.


Alphamab has fully integrated proprietary biologics platforms in bi-specifics and protein engineering. Its highly differentiated in-house pipeline consists of eight anti-cancer drug candidates, four of which have advanced into Phase I – III clinical development phases in China, US and Japan.  


The Company also has state-of-the-art manufacturing capability designed and built to meet NMPA and EU/FDA’s cGMP standards.Alphamab Oncology is committed to further develop its robust pipeline in oncology/immunology to benefit patients around the world. Visit http://www.alphamabonc.com for more information.


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